Table of Contents 1. Introduction 2. The normal cell 3. The genetic basis of disease 4. Cell response to injury 5. Connective tissue: its normal structure and the effects of disease 6. The acute inflammatory reaction 7. The body’s defences against infection 8. The pathogenesis of infection and the body’s response 9. Wound healing 10. healing in specialised tissues 11. Chronic inflammation 12. The immune system 13. Immunopathogenesis 14. Immunity to infection 15. Tissue transplantation 16. The HLA system-the major histocompatibility 17. Some pyogenic and other bacterial infections 18. Wound infections: the clostridia 19. Hospital infection 20. Tuberculosis, leprosy, syphilis and actinomycosis 21. Some interesting fungal, protozoal and other inflammatory conditions 22. Some smaller pathogenic organisms: rickettsiae, Chlamydia, mycoplasmas and viruses 23. Viral infections of humans 24. Disorders of growth 25. Tumours: introduction and classification 26. Structure and effects of some common neoplasms 27. Developmental tumours and tumour-like conditions 28. Spread of malignant tumours 29. The aetiology and incidence of tumours 30. The lymphoreticular system: the lymphomas 31. The effect of ionising radiation 32. The general reaction to trauma: haemorrhage and shock 33. Some disorders of metabolism 34. Disorders of nutrition 35. Disturbances of endocrine function 36. Calcium metabolism and heterotopic calcification 37. Temperature regulation: fever and hypothermia 38. Disturbances in the body’s fluid and electrolyte balance 39. General features of thrombosis and its occurrence in the venous system 40. Thrombosis in arteries and in the heart 41. Embolism 42. Ischaemia and infarction 43. Oedema 44. Heart failure 45. Respiratory failure 46. Renal failure 47. Hepatic failure and jaundice 48. Amyloidosis 49. The plasma proteins 50. Pigments of the body and their 51. Calculi 52. Some disorders of the blood: the red cells 53. Disorders of the blood: the white cells 54. Some platelet and coagulation defects 55. Blood grouping and blood transfusion