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Pronex-MUPS40 mg MUPS 10's Strip Tablet image
  • Pronex-MUPS40 mg MUPS 10's Strip Tablet image
  • Pronex-MUPS40 mg MUPS 10's Strip Tablet image
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Pronex-MUPS40 mg MUPS 10's Strip Tablet

Brand: Drug International Ltd

Category: Esomeprazole Magnesium

TK. 140 TK. 133 You Save TK. 7 (5%)
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Product Summary & Specification

Summary:

Indications of Pronex-MUPS 40 mg

Pronex-MUPS 40 mg is indicated: Treatment of Gastroesophageal Reflux Disease (GERD) Healing of erosive esophagitis Maintenance of healing of erosive esophagitis Symptomatic Gastroesophageal Reflux Disease (GERD) Reduction of NSAID-associated gastric ulcer H. pylori eradication (Triple therapy) Zollinger-Ellison syndrome।

Theropeutic Class

Proton Pump Inhibitor

Pharmacology

Pronex-MUPS 40 mg exerts its stomach acid-suppressing effects by preventing the final step in gastric acid production by covalently binding to sulfhydryl groups of cysteines found on the H /K -ATPase enzyme at the secretory surface of gastric parietal cells. This effect leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus. As the binding of Pronex-MUPS 40 mg to the H /K -ATPase enzyme is irreversible and new enzyme needs to be expressed in order to resume acid secretion, Pronex-MUPS 40 mg's duration of antisecretory effect that persists longer than 24 hours

Dosage of Pronex-MUPS 40 mg

Tablet or Capsule: Healing of erosive esophagitis: 20 mg or 40 mg once daily for 4 to 8 weeks. The majority of patients are healed within 4 to 8 weeks. For patients who do not heal after 4-8 weeks, an additional 4-8 weeks treatment may be considered. Maintenance of healing of erosive esophagitis: 20 mg once daily. Controlled studies did not extend beyond six months. Symptomatic GERD: 20 mg once daily for 4 weeks. If symptoms do not resolve completely after 4 weeks, an additional 4 weeks of treatment may be considered. H.pylori eradication (Triple therapy): Pronex-MUPS 40 mg 20 mg twice daily for 10 days, Amoxicillin 1000 mg Twice daily for 10 days and Clarithromycin 500 mg twice daily for 10 days Injection: The recommended adult dose in GERD with Erosive Esophagitis is either 20 or 40 mg Pronex-MUPS 40 mg given once daily by intravenous injection (no less than 3 minutes) or intravenous infusion (10 to 30 minutes).

Administration of Pronex-MUPS 40 mg

A solution for intravenous infusion is prepared by first reconstituting the contents of one vial with 5 ml of 0.9percent Sodium Chloride and further diluting the resulting solution to a final volume of 50 ml. The resultant concentration after diluting to a final volume of 50 ml is 0.8 mg/ml. 20 mg dose: Withdraw 25 ml of the final solution and administer as an intravenous infusion over 10 minutes to 30 minutes. 10 mg dose: Withdraw 12.5 ml of the final solution and administer as an intravenous infusion over 10 minutes to 30 minutes.

Interaction of Pronex-MUPS 40 mg

Pronex-MUPS 40 mg appears to be a selective inhibitor of the cytochrome P450 mono-oxygenase system, there may be an effect on hepatic clearance, but there have been no reports to date of clinically relevant interactions. There is some uncertainty over the effect of Pronex-MUPS 40 mg on the oral combined contraceptive pill. Physiological changes similar to those found with omeprazole are likely to take place because of the reduction in gastric acid which is likely to influence the bacterial colonization of the stomach and duodenum and also vitamin B12 absorption.

Contraindications

Pronex-MUPS 40 mg is contraindicated in those patients who have known hypersensitivity to any other components of the formulation.

Side Effects of Pronex-MUPS 40 mg

Side effects reported with Pronex-MUPS 40 mg include headache, diarrhea and abdominal pain.

Pregnancy and Lactation

US FDA pregnancy category of Pronex-MUPS 40 mg is C. So, Pronex-MUPS 40 mg should be avoided in pregnancy and lactation unless the potential benefits to the other outweigh the possible risks to the fetus.

Precautions and Warnings

Exclude the possibility of malignancy when gastric ulcer is suspected and before treatment for dyspepsia. When using in combination with antibiotic, refer to the prescribing information of the respective antibiotics.

Storage Conditions

Keep in dry place and away from light and heat. Keep out of the reach of children.

Reconstitution

Directions for reconstitution of solution: Solution for injection is prepared by adding 5 ml of 0.9percent Sodium Chloride for intravenous injection into the vial containing the dry powder. The reconstituted solution for injection is clear and colorless to very slightly yellow.
Specification:
Title: Pronex-MUPS40 mg MUPS 10's Strip Tablet
Brand: Drug International Ltd

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Brand Information

Drug International Ltd logo
Drug International Ltd

Drug International Limited started its journey in 1974 as a private limited company, etching its journey under the Registrar of Joint Stock Companies. We are the first manufacturer of soft gel medicine leading in Bangladesh. Since its establishment, the company has maintained a strong focus on producing high-quality medicines while adhering to international standards. With an expansive portfolio covering various therapeutic areas, Drug International is committed to innovation, excellence, and contributing to the healthcare needs of the population locally and globally. From day one, our unwavering mission has been to soar beyond boundaries, aligning with global standards. Guided by the World Health Organization's Good Manufacturing Practices (WHO cGMP) guidelines, we've been scripting a legacy of excellence, one milestone at a time.Drug International Limited continues to play a crucial role in the pharmaceutical industry of Bangladesh and abroad, with a strong commitment to producing safe, effective, and innovative medicines. By combining advanced technology, a dedicated workforce, and a customer-first approach, the company is positioned as a trusted name in healthcare solutions.

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Pronex-MUPS40 mg MUPS 10's Strip Tablet
Pronex-MUPS40 mg MUPS 10's Strip Tablet

৳ 133 ৳140.0

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